Rickets and osteomalacia in Saudi children and adolescents attending endocrine clinic, Riyadh, Saudi Arabia.
نویسندگان
چکیده
This is a retrospective study in which we report our clinical experience during the period from January 1990 to December 2009, from a paediatric endocrine clinic at King Khalid University Hospital (KKUH), Riyadh, Saudi Arabia. The diagnosis of rickets and oestomalacia was based on clinical, biochemical and radiological data. Eighty-one (34 males and 47 females) children and adolescents with rickets or osteomalacia aged 2 to 18 years (mean; 9.5 years) were evaluated. The commonest causes were nutritional; either low Vitamin D or calcium, or both. In 58 (71.60%) patients, eight patients (9.87%) were due to chronic use of anticonvulsant medications, while five (6.17%) patients were diagnosed to have celiac disease. Non-specific symptoms, such as bone pain and fatigue were the most common presenting symptoms which may indicate that other cases were possibly missed. Lack of direct sun exposure and malnutritional practices were evident. Several genetically inherited disorders were diagnosed; including; hypophosphataemic rickets in three (3.70%), vitamin D-dependent-rickets type 2 in five (6.17%) and pseudohypo-hyperparathyroidism in one (1.23%) child. Rickets was secondary to chronic renal failure in only one patient (1.23%). In conclusion, a diversity of disorders caused rickets or osteomalacia in our series. Paediatricians should be familiar with such different types and able to differentiate them from disorders mimicking rickets. rickets, such as hypophosphatasia, and metaphyseal dysplasias. An active plan should be put in place to prevent rickets and osteomalacia among young age groups.
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ورودعنوان ژورنال:
- Sudanese journal of paediatrics
دوره 12 1 شماره
صفحات -
تاریخ انتشار 2012